High quality 98% Thiocolchicoside 602-41-5
Name Thiocolchicoside
Molecular Formula C27H33NO10S
Molecular Weight 563.62
CAS Registry Number 602-41-5
EINECS 210-017-7
Thiocolchicoside is a Yellow crystalline Powder, soluble in water & alcohol.
Source
Thiocolchicoside is extracted from the seeds of Gloriosa Superba.
Gloriosa is a genus of five or six species in the plant family Colchicaceae, from tropical Africa and Asia. They are tender, tuberous rooted deciduous perennials, adapted to summer rainfall with a dormant dry season. Their native range is Africa, Southeastern Asia and parts of Malaysia, but they are now widely cultivated.
Gloriosa superba is the national flower of Zimbabwe, former Rhodesia (where it is a protected plant). It is also the state flower of Tamilnadu state in India.
Function
Thiocolchicoside is a muscle relaxant with anti-inflammatory and analgesic effects. It acts as a competitive GABAA receptor antagonist and also inhibits glycine receptors with similar potency and nicotinic acetylcholine receptors to a much lesser extent. It has powerful convulsant activity and should not be used in seizure-prone individuals.
Main functions are as follows:
1. Anti-cancer
2. Anti-gout
3. Cure chronic hepatitis and cirrhosis of liver
Application
Thiocolchicoside (Muscoril, Myoril, Neoflax) is a muscle relaxant with anti-inflammatory and analgesic effects. It acts as a competitive GABAA receptor antagonist and also glycine receptor antagonist with similar potency and nicotinic acetylcholine receptors to a much lesser extent. It has powerful convulsant activity and should not be used in seizure-prone individuals. This mechanism of action would be expected to induce withdrawal symptoms in gabaminergic (ex. barbiturates, carbamates, ethanol) dependent individuals, including the potentially lethal delerium tremens.
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