Customization: | Available |
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Powder: | Yes |
Customized: | Customized |
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Product Name: | D-Serine |
Synonyms: | D-(+)-SERINE;D-SERINE;D-2-AMINO-3-HYDROXYPROPIONIC ACID;D-2-AMINO-3-HYDROXYPROPANOIC ACID;D-BETA-HYDROXYALANINE;H-D-SER-OH;2-AMINO-3-HYDROXYPROPANOIC ACID;(R)-2-AMINO-3-HYDROXYPROPIONIC ACID |
CAS: | 312-84-5 |
MF: | C3H7NO3 |
MW: | 105.09 |
EINECS: | 206-229-4 |
Product Categories: | Amino Acid Derivatives;Serine [Ser, S];Amino Acids and Derivatives;alpha-Amino Acids;Amino Acids;Biochemistry;Amino Acids;Glutamate receptor;Glutamate;Amines;Inhibitors;Intermediates & Fine Chemicals;Neurochemicals;Pharmaceuticals;Pharmaceutical intermediates;D-Cycloserine intermediate;Lacosamide intermediate |
DSerine, synthesized in the brain by serine racemase from Lserine (its enantiomer), serves as both a neurotransmitter and a gliotransmitter by activating NMDA receptors, making them able to open if they then also bind glutamate.
Dserine is a potent agonist at the glycine site of the NMDAtype glutamate receptor. For the receptor to open, glutamate and either glycine or Dserine must bind to it. In fact, Dserine is a more potent agonist at the glycine site on the NMDAR than glycine itself. Dserine was only thought to exist in bacteria until relatively recently; it was the second D amino acid discovered to naturally exist in humans, present as a signalling molecule in the brain, soon after the discovery of Daspartate.
Items |
Specifications |
Results |
|
Appearance |
White crystals or crystalline powder |
Conforms |
|
pH |
5.2~6.2 |
5.72 |
|
Specific rotation |
-13.5°~-16.0° |
-15.25° |
|
State of solution |
≥95.0% |
98.50% |
|
Ammonium(NH4) |
≤0.02% |
<0.02% |
|
Iron(Fe) |
≤10ppm |
<10ppm |
|
Arsenic(As2O3) |
≤1ppm |
<1ppm |
|
Heavy metals, as Pb |
≤10ppm |
<10ppm |
|
Loss on drying |
≤0.25% |
0.08% |
|
Residue on ignition |
≤0.10% |
0.06% |
|
Assay |
98.5%~100.5% |
99.67% |