| Customization: | Available |
|---|---|
| Powder: | Yes |
| Customized: | Customized |
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Product Name |
Fasudil Hydrochloride |
|
Chemical Name |
6 H-1-(5-isoquinline sulfonyl)-1(H)-1 |
|
CAS NO |
105628-07-7 |
|
MF |
C14H17N3O2S·HCl |
|
MV |
327.83 |
|
Physical Character |
White or white like crystalline powder |
|
Functions and Usage |
Used for preventing and treating cardiovascular and cerebrovascular disease. |
|
Packing and Storage |
Packing: 1kg/bag. Shading seal preservation. |
|
Quality Standard |
Appearance: White or white like crystalline powder Acidity: PH4.5-6.0 Residue on Ignition: ≤0.1% Heavy Metals: ≤0.002% Related Substances: Single Impurity≤0.1% Total Impurity≤1.0% Water: ≤2.5% Assay: ≥99.0% |
Fasudil hydrochloride is a cell-permeable, selective ROCK inhibitor which induces neuroprotection in vitro. Studies suggest that when acting as a ROCK inhibitor, Fasudil reduces neutrophil transendothelial migration by diminishing cytoskeletal rearrangement of endothelial cells. In addition, Fasudil significantly protects against MeHg-induced axonal degeneration and apoptotic cell death in cultured cortical neurons. Alternate studies show that Fasudil plays an important role in osteoblastic differentiation of stromal cells via increasing the mRNA expression of collagen-I, osteocalcin, and bone morphogenetic protein-2 (BMP-2). Furthermore, noggin, a BMP-2 antagonist can reverse the effects of Fasudil induced mRNA expression of collagen-I and osteocalcin. Upon inhibition of Rho-kinase, Fasudil significantly stimulates FGF-2-induced accumulation of vascular endothelial growth factor . Fasudil, Monohydrochloride Salt is an inhibitor of cGKI, MSK1, PKA, PRK2, Rock-2, AMPK, CaMKII, Polycystin-1 and Rsk-1.
Fasudil Hydrochloride is a new drug with a wide range of pharmacological effects, developed by Asahi Kasei Corporation (Japan.) It is a cardiovascular and cerebrovascular drug which improves symptoms of ischemic cerebrovascular disease such as cerebral vasospasm following subarachnoid hemorrhage. It has significant neuroprotective and therapeutic effects for ischemic cerebrovascular disease, and is suited for clinical use, particularly at the grassroots level to reduce mortality and improve quality of life.
Fasudil Hydrochloride is an isoquinoline sulfonamide derivative which can relax separated cerebral blood vessels, inhibit the shrinkage of separated blood vessels caused by calcium influx, inhibit different mechanisms of brain blood vessel contraction from contractile agents, and inhibit intracellular calcium ion activity without reducing calcium ion concentration. Fasudil Hydrochloride is an RHO kinase inhibitor which dilates vessels, reduces tension of endothelial cells, and improves microcirculation of brain tissue without producing or exacerbating diversion of blood to the brain, by increasing activity of myosin light chain phosphatase. At the same time, it can protect nerves against apoptosis and promote their regeneration. Fasudil Hydrochloride promotes recovery of neural function and reduces clinical symptoms.
|
Appearance |
White or off-white crystalline powder |
|
Assay |
99%min |
|
Indentification |
|
|
UV |
Meets the requirements |
|
IR |
Consistent with reference specturm |
|
Chemical reaction |
Meets the requirements
|
|
Color or solution |
not more intensely colored than refrence solution |
|
Clarify of solution |
not more palescent than refrence suspension solution |
|
Related substance |
single impurity: 0.1%max |
|
Total impurity:1.0%max |
|
|
PH |
4.5-6.0 |
|
Dimethylformamide |
0.088%max |
|
Aether |
0.5%max |
|
Methanol |
0.3%max |
|
|
0.06%max |
|
Moisture |
2.5%max |
|
Residue on ignition |
0.1%max |
|
Heavy metals |
0.002%max |
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