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4-Pyridinecarboxylic Acid Isonicotinic acid powder 99% CAS 55-22-1
Iso-niacin is also known as pyridine-4-formic acid. White acicular crystal. No smell, sublimate. Molecular weight 123.11. Melting point is 319 ºC. Slightly soluble in cold water, soluble in Chemicalbook hot water, insoluble in alcohol, benzene, ether. Amphoteric compounds that dissolve in both acids and bases. Soluble in hot water and ethanol, slightly soluble in cold water and ether. Stable to heat and oxidation.
Isonicotinic acid is a widely used intermediate, mainly as the raw material of isoniazid (remicide), terfenadine and isonicotinate and other first-line anti-tuberculosis drugs, but also as anti-corrosive agents, plating additives, photosensitive resin stabilizer, polyvinyl chloride heat stabilizer and non-ferrous metal flotation agents.
Isonicotinic acid is a widely used intermediate, mainly as a raw material for first-line anti-tuberculosis drugs such as isoniazid (ramicide), terfenadine and isonicotinate, but also as an anti-corrosive agent, electroplating additive Chemicalbook, photosensitive tree stabilizer, polyvinyl chloride heat stabilizer and non-ferrous metal flotation agents. Isoniazid can be prepared by condensing isoniazid with hydrazine hydrate and melting for dehydration. Isoniazid has good resistance to MYCObacterium tuberculosis
Product Name |
Isonicotinic Acid |
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Batch No. |
AR20200128 |
Mfg. date |
2020-01-28 |
Test Date |
2020-02-01 |
Exp. date |
2022-01-27 |
Tests |
Specifications |
Results |
|
Description |
Yellow-brown powder, very hygroscopic. |
Yellow-brown powder, very hygroscopic. |
|
Solubility |
Freetly soluble In water and methanol and dichloromethane |
Complies |
|
Identification |
(1)By IR, To match with working standard |
Complies |
|
(2)It gives reaction of sodium |
Complies |
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Impurities A |
≤0.1% |
Not detected |
|
Related compounds |
Any impurity ≤0.1% |
<0.1% |
|
Total impurities ≤0.4% |
0.25% |
||
Residual Solvents |
Acetidin≤ 0.5% |
Not detected |
|
Dichloromethane≤ 0.06% |
Not detected |
||
Methanol≤ 0.3% |
Not detected |
||
Acetone ≤ 0.5% |
Not detected |
||
Acetonitrile≤0.041% |
Not detected |
||
Ethanol≤0.5% |
0.04% |
||
N, N-dimethylformamide≤0.088% |
Not detected |
||
Water |
≤ 5.0% |
1.38% |
|
Assay |
99.0%-101.0%(On anhydrous basis) |
99.98% |
|
Conclusion |
Conform to EP8.0 |